The Journal of Biological Physics and Chemistry

2012

 

Volume 12, Number 1, pp. 1922

 

 

 

The study of blood serum proteins in patients with mammary gland tumours

J. Monaselidze,1 T. Tevdoradze,2 M. Zibzibadze,2 M. Alibegashvili,2 L. Ramishvili,2 M. Gordeziani2 and N. Kotrikadze2 

Institute of Physics, Iv. Javakhishvili Tbilisi State University (TSU), 6 Tamarashvili Street, 0177 Tbilisi, Georgia

Division of Cellular and Molecular Biology, Department of Biology, Faculty of Exact and Natural Sciences, Iv. Javakhishvili Tbilisi State University (TSU), 13 University Street, 0177 Tbilisi, Georgia

One of the manifestations of tumour progression is the quantitative and qualitative alteration of blood proteins. Therefore, the study of serum proteins in oncological patients carries a possible diagnostic significance. The goal of this work was to define serum protein alterations in menopausal patients with mammary gland tumours and to evaluate the possible diagnostic significance of the methods that have been applied: polyacrylamide gel electrophoresis (PAGE) and differential scanning calorimetry (DSC) were used. As evidenced by PAGE there were no significant changes in menopausal patients with benign and malignant tumours of the mammary gland compared with the control group, while DSC revealed significant changes in several blood protein fractions. The differences observed on the thermograms enabled us to differentiate benign and malignant tumours of the mammary gland, confirming the possibility of diagnostic usefulness of the method.

Keywords: differential scanning calorimetry, mammary gland tumours, serum proteins

 

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