Volume 4, Number 3, p. 157–161
Immunomodulating and antitumour effects of basidiomycetes Pleurotus ostreatus (Jacq.: Fr.) P. Kumm. and P. cornucopiae (Pau. ex Pers.) Rollan
M.M. Shamtsyan,1 V.G. Konusova,2 A.M. Goloshchev,1 Y.O. Maksimova,1 A.V. Panchenko,3 N.N. Petrishchev3 and N.P. Denisova4
1Department of Technology of Microbiological Synthesis, St.Petersburg State Institute of Technology (Technical University), 26 Moskovsky Prospect, 198013 St Petersburg, Russia
2Laboratory of Immunopharmacology, State Research Institute of Highly Pure Biopreparations, 7 Pudozhskaya St, 197110 St Petersburg, Russia
3Department of Pathological Physiology, Academician I.P. Pavlov St Petersburg Medical University, 6/8 L. Tolstoy St, 197022 St Petersburg, Russia
4Laboratory for the Biochemistry of Mushrooms, V.L. Komarov Botanical Institute, Russian Academy of Sciences, 2 Prof. Popov St, 197376 St Petersburg, Russia
Water extracts from fruit bodies and mycelia of Pleurotus ostreatus (Jacq.: Fr.) P. Kumm. and P. cornucopiae (Pau. ex Pers.) Rollan were studied for reliable beneficial biological effects. In vitro and in vivo experiments were carried out. It was shown that the preparations demonstrated many types of marked biological effects, notably increasing the production of reactive oxygen formed by neutrophils of peripheral human blood; marked mitogenic activity over a wide range of concentrations; co-stimulating effects on interleukine 1-b production by peripheral blood cells; immunostimulating action involving almost all immunocompetent cells; promoting the main cells—neutrophils—of the inflammatory response causing not only chemotaxis but also an oxygen burst showing activation of the phagocyotic response; decreasing both average tumour size in mice with transplanted melanoma B-16 and tumorous intoxication, prolonging the survival rate of such mice up to 2.5 times.
Keywords: antitumour effect, cytokines, extracts, immunomodulation, melanoma, Pleurotus