þÿ<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN"> <HTML> <head> <meta http-equiv="Content-Type" content="text/html; charset=utf-8"> <title>JBPC Vol. 7, 2, 2007 ABSTRACT </title> </head> <body link="#0000FF"><center><h1><font color="#006600">The Journal of Biological Physics and Chemistry</font></h1></center> <p></p><p></p> <b><center>2007<p>Volume 7, Number 2, p.p. 45 50</center></b> <br> <div> <p><b><font size=+2> Modelling of the TH-dependent regulation of tadpole tail resorption </font></b></p> <p> <b> S. Troncale,<sup>1,*</sup> R. Thuret,up<sup>2</SUP> A.-C. Fierro,<SUP>2</SUP> C. Ben,<SUP>2</SUP> N. Pollet,<SUP>2</SUP> J.-P. Comet<SUP>1, 3</SUP> and G. Bernot<SUP>3</SUP> </b> <br> <br> <i> <SUP>1</SUP>IBISC, FRE 2873, Université d Evry Val-d Essonne, Génopole, France<BR> <SUP>2</SUP>Laboratoire de Développement et Evolution, UMR 8080, Université de Paris Sud, France<BR> <SUP>3</SUP>Programme d Epigénomique, Génopole et Université d Evry, France </i></p> <P align=justify> Tail resorption observed at the time of amphibian metamorphosis is controlled by the thyroid hormone (TH). The inherent regulation network is complex and involves an important number of different factors. Consequently, global understanding of this biological process needs elaborate experiments. However, these experiments may be difficult to realize because of the need to manipulate in space and in time gene expression and hormonal treatments. Hence, we first modelled and simulated the biological process using Hybrid Functional Petri Nets. This powerful formalism offers a number of useful features and flexibility. Curves obtained<I> in silico</I> by simulations are in agreement with those observed <I>in vivo</I> and<I> in vitro.</I> Our modelling approach led us to ask pertinent biological questions, from which new hypotheses for experimental testing have emerged. </p> <b>Keywords: </b> Hybrid Functional Petri Nets, metamorphosis, modelling, tail resorption, thyroid hormone </p> <br> </div> <p></p> <center><p><i><font size=-1><a href="jbpc20707.html">back to contents</a></font></i></p></center> </body> </html>